FSTL3 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comFSTL3 Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > FSTL3(Gene name) > Human

FSTL3 (Gene name),

Follistatin-related protein 3 (Protein name ), FSTL3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FSTL3(UNQ674/PRO1308;FLRG);

Protein name:

Follistatin-related protein 3;

Alternative:

Follistatin-related gene protein;Follistatin-like protein 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Isoform 2 interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN.

Function:

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Subcellular Location:

Isoform 2 Nucleus Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initation at Met-27 according to.

Protein Attributes:

Sequence length:

263

Sequence:

50:

100:

150:

200:

250:

263:

PGGESAEEEE | NFV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

605343

String:

O95633

STRING:

9606.ENSP00000166139

UniGene:

Hs.529038

KEGG:

hsa:10272

SMR:

O95633

Pfam:

PF09289

Uniprot:

O95633

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ELISA Kit for Human Follistatin-related protein 3

Cat.:

E0127b

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96T

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ELISA Kit for Human Follistatin-related protein 3

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E0127m

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96T

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ELISA Kit for Human Follistatin-related protein 3

Cat.:

E0127r

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ELISA Kit for Human Follistatin-related protein 3

Cat.:

E0127h

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96T

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CLIA Kit for Human Follistatin-related protein 3

Cat.:

U0127h

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96T

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CLIA Kit for Human Follistatin-related protein 3

Cat.:

U0127m

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MSDS:

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Packing:

96T

CLIA Kit for Human Follistatin-related protein 3

Cat.:

U0127b

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96T

CLIA Kit for Human Follistatin-related protein 3

Cat.:

U0127r

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96T

Polyclonal Antibody for Human Follistatin-related protein 3

Cat.:

P0127Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Follistatin-related protein 3

Cat.:

P0127Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Follistatin-related protein 3

Cat.:

P0127Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Follistatin-related protein 3

Protein for Human Follistatin-related protein 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders."
Hayette S. , Gadoux M. , Martel S. , Bertrand S. , Tigaud I. , Magaud J.-P. , Rimokh R.
Oncogene16:2949-2954(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION
tissue: Placenta.
2.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
6.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-41
7.

"Human follistatin-related protein: a structural homologue of follistatin with nuclear localization."
Tortoriello D.V. , Sidis Y. , Holtzman D.A. , Holmes W.E. , Schneyer A.L.
Endocrinology142:3426-3434(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
8.

"Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function."
Bartholin L. , Maguer-Satta V. , Hayette S. , Martel S. , Gadoux M. , Corbo L. , Magaud J.P. , Rimokh R.
Oncogene21:2227-2235(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)."
Schneyer A. , Schoen A. , Quigg A. , Sidis Y.
Endocrinology144:1671-1674(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INHBA AND INHBB
10.

"Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells."
Wang H.Q. , Takebayashi K. , Tsuchida K. , Nishimura M. , Noda Y.
J. Clin. Endocrinol. Metab.88:4432-4439(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
11.

"FLRG, member of the follistatin family, a new player in hematopoiesis."
Maguer-Satta V. , Rimokh R.
Mol. Cell. Endocrinol.225:109-118(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HEMATOPOIESIS
12.

"FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation."
Bartholin L. , Destaing O. , Forissier S. , Martel S. , Maguer-Satta V. , Jurdic P. , Rimokh R.
Biol. Cell97:577-588(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN OSTEOCLAST DIFFERENTIATION;INTERACTION WITH ADAM8 AND ADAM12
13.

"Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3."
Saito S. , Sidis Y. , Mukherjee A. , Xia Y. , Schneyer A.
Endocrinology146:5052-5062(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ALTERNATIVE INITIATION;MUTAGENESIS OF MET-27
14.

"A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin."
Maguer-Satta V. , Forissier S. , Bartholin L. , Martel S. , Jeanpierre S. , Bachelard E. , Rimokh R.
Exp. Cell Res.312:434-442(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HEMATOPOIESIS;INTERACTION WITH FN1
15.

"AF10-dependent transcription is enhanced by its interaction with FLRG."
Forissier S. , Razanajaona D. , Ay A.S. , Martel S. , Bartholin L. , Rimokh R.
Biol. Cell99:563-571(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTION REGULATION;INTERACTION WITH MLLT10
16.

"Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development."
Takehara-Kasamatsu Y. , Tsuchida K. , Nakatani M. , Murakami T. , Kurisaki A. , Hashimoto O. , Ohuchi H. , Kurose H. , Mori K. , Kagami S. , Noji S. , Sugino H.
J. Med. Invest.54:276-288(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MSTN
17.

"The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity."
Stamler R. , Keutmann H.T. , Sidis Y. , Kattamuri C. , Schneyer A. , Thompson T.B.
J. Biol. Chem.283:32831-32838(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF 27-263 IN COMPLEX WITH INHBA;DISULFIDE BONDS;GLYCOSYLATION AT ASN-215
18.

"Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding."
Cash J.N. , Angerman E.B. , Kattamuri C. , Nolan K. , Zhao H. , Sidis Y. , Keutmann H.T. , Thompson T.B.
J. Biol. Chem.287:1043-1053(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 36-244 IN COMPLEX WITH MOUSE GDF8;GLYCOSYLATION AT ASN-73;DISULFIDE BONDS

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